National Federation of the Disabled Nepal (NFD-N) is happy to share general guidelines and recommendations for persons with disabilities, caretakers, parents, Disabled Peoples Organizations, service provides, government institutions, organizations working on disability issues and all relevant stakeholders on the disability-inclusive response against COVID-19 pandemic. This guideline has been developed by NFD-N in the context of Nepal based on the organizational experience of NFD-N, official information provided by WHO, official information provided by Nepal Government and the recommendations from International Disability Alliance (IDA) on COVID-19. We expect that this guideline would be helpful for all stakeholders to address the issues of persons with disabilities in all preparatory works and responses against COVID-19 in Nepal.